Advances in the Diagnosis of Chronic Lymphoid Neoplasms in Côte d'Ivoire: Toward Improvement

This study aims to provide a comprehensive overview of Chronic Lymphoproliferative Disorders (CLPDs) in Côte d'Ivoire, focusing on recent advancements in diagnostic techniques to improve patient management. The study characterizes CLPDs in Côte d'Ivoire, highlighting advancements in diagnostic methods that may enhance patient care. A cross-sectional study was conducted, including 51 patients with lymphocytosis >5000/mm³. Cytological and immunophenotypic analyses were performed using flow cytometry to identify and classify CLPDs. The results showed that among the 51 cases of CLNs identified, B-cell proliferations accounted for 82%, while T-cell proliferations constituted 18%. Chronic lymphocytic leukaemia (CLL) was predominant. Immunophenotyping revealed distinct marker profiles, enabling subtype differentiation. While cytology remains relevant, emphasis was placed on integrating immunophenotyping and molecular techniques for accurate diagnosis. The combination of flow cytometry with other molecular biology techniques has been recognized as a significant advancement in the field. Further integration of cytogenetics and molecular biology aims to refine diagnostic accuracy and treatment strategies.